Fine mapping of the a-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer’s disease pedigrees
نویسندگان
چکیده
Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA, Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic Rochester, Rochester, MN, USA, Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA and Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL, USA
منابع مشابه
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Using plasma amyloid beta protein (Abeta42) levels as an intermediate, quantitative phenotype for late onset Alzheimer's disease (LOAD), we previously obtained significant linkage at approximately 80 cM on chromosome 10. Linkage to the same region was obtained independently in a study of affected LOAD sib-pairs. Together, these two studies provide strong evidence for a novel LOAD locus on chrom...
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